Research and Development

Doctora Mariela Guevara
Doctor

Mariela Guevara

Dr. Mariela Guevara is the Senior Advisor for the LifEscozul™ Group's Clinical Trials to be developed in 2021.

As part of the Health Registration process, she is the person in charge of preparing the protocols associated with the trials and their control.

Dr. Mariela Guevara has a vast experience in the management of clinical trial protocols enriched with more than 10 years working on the blue scorpion venom issue.

STUDIES

2015 - 2016

Master in Translational Research and Clinical Trials. University of Extremadura. Spain.

2007 - 2008

Diploma in Oxidative Stress. Health and disease. Institute of Pharmacy and Food. University of Havana. Cuba.

2003

Second Degree Specialist in Pharmacology. At the Facultad Docente Salvador Allende Higher Institute of Medical Sciences of the University of Havana.

1997

First Degree Specialist in Pharmacology. At the Facultad Docente Calixto García Higher Institute of Medical Sciences of the University of Havana.

1991

Doctor of Medicine at the Finlay - Albarrán Faculty, Higher Institute of Medical Sciences of the University of Havana.

WORK EXPERIENCE

2019 - Current

Advisor for clinical trials for Lifescozul Group Chile SpA. - Chile.

Doctora Mariela Guevara
Doctora Mariela Guevara
Work Experience

Pharmaceutical

1998 - 2009

Pharmacological Research Group. Center of Pharmaceutical Chemistry. Cuba.

1991 - 1997

Resident of Clinical and Experimental Pharmacology. University of Havana. Cuba.

Work Experience

Teaching

Professor - researcher of the Faculty of Health Sciences. Pedro Henríquez Ureña National University. (UNPHU). Dominican Republic.

Assistant Professor of Pharmacology and Physiology. Faculty of Medicine No. 3 Finlay - Albarrán.

Universidad de La Habana, Cuba.
Subjects taught:

  • - General Physiology.
  • - General Pharmacology and Toxicology, undergraduate and graduate (residents).
  • - Research Methodology
Work Experience

RESEARCH AND DEVELOPMENT

2009 - 2016
  • - Clinical studies on the use of an extract of Mangifera indica L. (Vimang) in inflammatory and oxidative stress states.
  • - Quality of clinical research.
  • - Research to automate databases in laboratories of sites participating in Clinical Trials.
  • - Clinical trials on the use of Ferrical as an antianemic.
  • - Clinical trials on the use of Nutrisol in nutritional disorders.
  • - Development of dossier for authorization to start a clinical trial with RLN-01 (Rophalurus junceus scorpion venom).

2004 - 2008

Head of Project of the Ministry of Science, Technology and Environment of Cuba (CITMA): Evaluation of the effect of a natural extract of Mangifera indica L. on diseases related to oxidative stress: Ischemic Cerebrovascular Disease and Diabetes Mellitus Type I.

2003 - 2009

Head Project of the Ministry of Public Health of Cuba (MINSAP) Evaluation of the effect of an extract of Mangifera indica L. in spinocerebellar ataxia type 2. Oxidative stress and neurophysiological studies in ataxic patients type SCA2.

2002 - 2003

Evaluation of the effect of Vimang supplementation on indicators of oxidative stress and disease progression in HIV/AIDS patients..

1998 - 2008

Pharmacological studies of natural extracts with biological activity. Oxidative stress and inflammation. Main mediators. In vitro and in vivo biological models.

Work Experience

MEMBERSHIP IN SCIENTIFIC SOCIETIES

2009 - 2016
  • - Founding member of the Cuban Society of Pharmacology.
  • - Member of the Cuban Society of Pharmacy.
  • - Full member of the Spanish Society of Pharmacology.
Doctora Mariela Guevara
MAIN COURSES RECEIVED

PHARMACEUTICAL INDUSTRY

2015 - 2016

Master in Translational Research and Clinical Trials. University of Extremadura. Spain.

2007 - 2008

Diploma: Oxidative Stress. Health and disease. Institute of Pharmacy and Food. University of Havana. Cuba.

2004

Investigación clínica. CeVEAS (Center for the Evaluation of the Effectiveness of Health Care, Módena, Italy). Italian Cochrane Center. Mario Negri Institute for Pharmacological Research, Milan, Italy. Italy.

2003

V International Meeting on Basic and Clinical Immunology Update. Surgical Research Medical Center. Cuba.

2002

First Latin American Conference on Research, Development and Innovation of related compound drugs. Spanish Agency for International Cooperation (CYTED). Guatemala.

2002

Course: Industrial Property. Center of Pharmaceutical Chemistry - Cuban Industrial Property Office. Cuba.

2001

Course on Immunology in infectious diseases. Pedro Kourí Institute - Cuban Society of Immunology - Harvard School of Public Health - Harvard School of Medicine - WHO. Cuba.

1998

Methodological aspects in the development of bioavailability and bioequivalence studies. National Center of Toxicology. Cuba.

1998 - 2001 - 2012

Orthomolecular Medicine. Biological Research Center. University of Havana, Cuba.

1996

General Toxicology of Drugs. University of Havana, Institute of Preclinical and Basic Sciences. Cuba.

Ver más

AWARDS

2019

Investigador Titular. MESCYT.

2013

PREMIO NACIONAL DE FARMACOLOGÍA: Caracterización de variables de estrés oxidativo en diferentes condiciones clínicas.

2013

PREMIO LATINOAMERICANO DE FARMACOLOGÍA DR. PLUTARCO NARANJO IN MEMORIAN: Caracterización de variables de estrés oxidativo en diferentes condiciones clínicas.

2008

PREMIO SOCIEDAD CUBANA DE FARMACOLOGÍA: Mención modalidad reviews (Artículos Científicos de Revisiones Temáticas). The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract. (Publicado en: Pharmacological Research 55: 351–358, 2007).

2014

III International Congress Health science CICS-UDABOL, Bolivia. "Potentialities of RjLB-14 peptide for anticancer treatment." (conference).

MAIN INTERNATIONAL PUBLICATIONS

2016

Protocol of Determining the Effect of Vimang™ and Spirel™ Supplementation in Aids Patients with Delayed Diagnosis of HIV: An Open Randomized Controlled Trial. Journal of AIDS & Clinical Research 7(5).

2015

Oxidant/antioxidant status in subjects with HIV infection in different clinical conditions. July 2015. Biomedicine and Aging Pathology 4(3):235–242.

2012

Altered redox status in Cuban patients with spinocerebellar ataxia type 2. Biomedicine & Aging Pathology;2:24–29.v

2012

Characterization of oxidative stress in different clinical conditions, using redox indexes of diagnostic value. Biotecnología Aplicada;29,(3):1-9.

2012

Systems biology of antioxidants. Clinical Science;123, 173–192.

2012

Oxidative stress as a cofactor in spinocerebellar ataxia type 2. Redox Report;17(2):84-89.

2007

Experimental evidences of a mango stem bark extract. Pharmacological Research 55; 351–35.

2007

Vimang™. Recent advances in the research & development of an aqueous stem bark extract obtained from Mangifera indica L. Recent Developments in Medicinal Plant Research: 169-192 ISBN: 978-81-308-0160-5.

2007

Efecto de la Crema Antioxidante Vimang™ en Enfermedades Dermatológicas. Lat. Am. J. Pharm. 26 (2): 237-42.

2004

Extracto natural de Mangifera indica L. (VIMANG™): de la etnomedicina a la clínica. BLACPMA 3(6):107-109.

2004

Evaluación del efecto y seguridad del Ribofén en el tratamiento de la Artritis Reumatoide. Acta Farmacológica Bonaerense 23(4):437-41.

2002

Effects of Vimang on oxidative Stress and marker of disease progression in HIV/AIDS patients. Free Radical Research. Volume 36, Supplement 1. ISSN 1071- 5762.

2001

Vimang as natural antioxidant supplementation in patient with malignant tumours. MINERVA MEDICA;92 (Supl. 1 al N. 3): 95-7

Ver más

PUBLICATIONS IN BOOKS WITH EDITORIAL BOARD

2010

“Vimang: Experiences from the Antioxidant Therapy in Cuban Primary Health Care” en V.K. Gupta, A.K. Verma (Eds.) Comprehensive Bioactive Natural Products Studium Press, Houston. Vol. IV, Ch. 14, p. 259-71, ISBN 1-933699-54.

2008

EL RETO EN LA TERAPIA ANTIOXIDANTE. LIBRO. Editorial Científico-Técnica. Cuba. ISBN 978-959-05-0525-6.

2007

Recent advances in the research & development of and aqueous stem bark extract from Mangifera indica L. In: Recent Developments in Medicinal Plant Research, Editor: Anna Capaso, Research Signpost, Kerala, India, (ISBN: 978-81-308-0160), pp. 169-192.

PARTICIPATION WITH EXHIBITION OF WORKS IN INTERNATIONAL EVENTS

2012

5TH EUROPEAN CONGRESS FOR INTEGRATIVE MEDICINE (ECIM 2012). Florence. Use of Vidatox 30CH in patients with advanced tumors.

2010

16TH WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY. Bellacenter, Copenhagen, Denmark. Symposium on Antioxidants as Therapeutic Agents: Oxidative stress and spinocerebellar ataxia type 2. Mariela Guevara. Guest speaker.

2009

X CONGRESO IBEROCENTROAMERICANO Y DEL CARIBE DE ENFERMEDAD NEUROLÓGICA CRÓNICA Y EPILEPSIA. Guatemala. Guest Professor.

2008

XVIII CONGRESO DE LA ASOCIACIÓN LATINOAMERICANA DE FARMACOLOGÍA. III CONGRESO IBEROAMERICANO DE FARMACOLOGÍA. Coquimbo, Chile. Pharmacological research of Mangifera indica L Stem bark extract and its glucosylxanthone mangiferin. Cuban Natural products with therapeutics impact.

2008

IX WORLD CONFERENCE ON CLINICAL PHARMACOLOGY AND THERAPEUTICS, Quebec City, Canada. Cuban Traditional Medicine with Natural Products. From the Ethnomedicine to the Clinical Pharmacological Evaluation. Mangifera indica L. Stem Bark Extract (Vimang) like an example with High Therapeutic Impact.

2008

CONGRESO INTERNACIONAL IMMUNOPHARMACOLOGY, I INTERNATIONAL WORKSHOP OF IMMUNOPHARMACOLOGY, V INTERNATIONAL WORKSHOP OF INFLAMMATION AND PAIN, I INTERNATIONAL WORKSHOP OF NEUROIMMUNOLOGY. I INTERNATIONAL SYMPOSIUM ABOUT PHARMACOLOGY OF CYTOCHROME P450. Varadero. Treatment of atopic dermatitis with an aqueous extract of Mangifera indica L. (VIMANG).

2007

III CONGRESO INTERNACIONAL DE FARMACOLOGÍA Y TERAPÉUTICA, VII CONGRESO NACIONAL DE LA SOCIEDAD CUBANA DE FARMACOLOGÍA, V WORKSHOP NACIONAL DE FARMACOEPIDEMIOLOGÍA, I SIMPOSIO NACIONAL DE ACTUALIZACIÓN FARMACOTERAPÉUTICA EN ONCOLOGÍA, OFTALMOLOGÍA Y ENDOCRINOLOGÍA Y I SIMPOSIO CUBA – CANADÁ DE HOMEOPATÍA. Cuba.

2007

IV TALLER INTERNACIONAL DE DISEÑO Y CONDUCCIÓN DE ENSAYOS CLÍNICOS. Cuba.

2007

PHARMACOLOGY HAVANA. “Researh with natural products. An extract of mangifera indica L.: from natural supplements to a new phytomedicine”. Cuba.

2007

EUROPEAN TRADICIONAL MEDICINE. Vimang: Ethnomedicine and clinical trials. Italy.

2007

ETM-2007. EUROPEAN INTERNATIONAL CONGRESS OF ALTERNATIVE MEDICINE, Vinci, Italia. “Results and experiences of the cuban traditional medicine with natural products. From the ethnomedicine to the deep pharmacological research”. Resumen publicado en eCAM 2007; 4(S1):53-54.

2006

FIRST INTERNATIONAL SYMPOSIA ABOUT PHARMACOLOGY OF NATURAL PRODUCTS AND BLACPMA. Varadero, Cuba. FAPRONATURA 2006. Varadero. Pharmacological Activities and Therapeutic Potentiality of Natural Extract Obtain from Stem Bark of Mangifera indica L (VIMANG) and its Glucosylxanthone, Mangiferin.

2006

15TH WORLD CONGRESS OF PHARMACOLOGY, Beijing, China. New Cuban Natural Product from Stem Bark of Mangifera Indica L (Vimang). Pharmacological profile and therapeutic potentiality.

2006

3RD INTERNATIONAL WORKSHOP ON VACCINE ADJUVANTS AND GLYCONJUGATES. Club Amigo Varadero, Cuba. 146- Inmunomodulatory properties of natural product obtain from stem bark of Mangifera indica L and its glucosilxantona, mangiferin.

2005

II SIMPOSIO INTERNACIONAL DE ATAXIAS HEREDITARIAS. Hotel Pernix, Holguin, Cuba.

2004

III TALLER INTERNACIONAL DE DISEÑO Y CONDUCCIÓN DE ENSAYOS CLÍNICOS. HOTEL OCCIDENTAL MIRAMAR, CUBA. Efecto del Vimang (tabletas 300 mg) en el estrés oxidativo asociado a la edad.

2003

PRIMER CONGRESO INTERNACIONAL LONGEVIDAD SATISFACTORIA: VISIÓN INTEGRAL “EL MAYOR RETO DEL HOMBRE EN EL NUEVO SIGLO. HOTEL NACIONAL, LA HABANA, CUBA. Impacto terapéutico y nutracéutico de una nueva línea de productos naturales cubanos derivados de la corteza de Mangifera indica L (Vimang). (Conferencia magistral).

2003

II CONFERENCIA INTERAMERICANA DE FARMACIA Y NUTRICIÓN. IFAL, UNIVERSIDAD DE LA HABANA, HOTEL NACIONAL DE CUBA. Pre-clinical evidence and therapeutic potentiality of Mangifera indica L. extract (Vimang), a new cuban natural product. (Conferencia).

2002

ATAXIA, PRIMER SYMPOSIUM INTERNACIONAL DE ATAXIAS HEREDITARIAS, SEGUNDO ENCUENTRO CARIBEÑO DE DEMENCIAS. HOLGUÍN, CUBA. Oxido nítrico y enfermedades neurodegenerativas. Desequilibrio redox en pacientes con ataxia SCA2. Conferencia.

2002

XIV International AIDS Conference. Barcelona, España. Evaluation of oxidative stress markers and CD4, CD38, CD95 positive T limphocytes subsets in HIV/AIDS patients.

2001

International Congress Herbal Medicines and Cancer. Italy. Vimang as natural antioxidant supplementation in patient with malignant tumours.

2001

INTERNATIONAL CONGRESS “HERBAL MEDICINE AND CANCER”, PALACIO DE CONGRESOS, FLORENCIA, ITALIA. Mangifera indica L extract (VIMANG) as a natural antioxidant with antinociceptive and anti-inflammatory properties.

2000

VII World Conference on Clinical Pharmacology and Therapeutics, IUPHAR & 4TH Congress of The European Association for Clinical Pharmacology and Therapeutics (EACPT), FLORENCIA, ITALIA. British J Clinical Pharmacol, Special Suplem CPT, pag 138.

Ver más

LANGUAGES

Spanish - Native
English - Intermediate